10. A 56 y/o chronic tobacco smoker reports he has recently been…
10. A 56 y/o chronic tobacco smoker reports he has recently been diagnosed with COPD which of the following pharmacokinetic processes in this individual could impact drug clearance? Absorption (b, c are incorrect)
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a. Elimination
b. metabolism
c. Distribution
d. Absorption
17. Certain benzodiazepines are more fat-soluble than other medications within this same class. The PMHNP knows that psychotropics that are primary fat-soluble (a,c are incorrect)
a. Do not cross the blood brain barrier
b. Have a tendency to cause the same therapeutic response in the general population
c. Are stored very briefly in the body
d. None of above
22. In general, the mechanism of action for an SSRI can be contributed to which of the following? (a, c incorrect)
- Induction of the 5HT transporter and subsequent increase of serotonin in the synaptic cleft
- Inhibition of the NE transporter and induction of the 5HT transporter, increasing serotonin in the synaptic cleft
- Inhibition of DA transporter and 5HT transporter, increasing serotonin presynaptic vesicles prior to synaptic release
- None of above
25. Often, the bioavailability of trade name of brand form of a psychotropic can differ significantly from its genetic form. If a patient with atypical depression is prescribed Bupropion rather than Wellbutrin, what statement may be true for this patient? (b, c incorrect)
- Wellbutrin could have less bioavailability, contingent upon parenteral administration
- Bupropion bioavailability depends upon the percentage of administrated dose that inactivated in systemic circulation
- Bupropion’s bioavailability is contingent upon the percentage of prescribed dose circulating in the bloodstream
- None of the above a
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